Veterinary Medicine Ivermectin Tablets for Dewormer for Cattle and Sheep
|Pharmacological effect||Pharmacodynamic :ivermectin mainly has good repellent effect on nematodes and surface arthropods in vivo. The mechanism of its repellent effect is to promote the release of y-aminobutyric acid (GABA) from presynaptic neurons, thereby opening GABA-mediated chloride channels. Ivermectin also has selectivity and high affinity for glutamatergic chloride channels located near GABA-mediated sites in invertebrate nerve and muscle cells, thereby interfering with neuromuscular signaling to relax and paralytize insect bodies, leading to death or expulsion of insect bodies. Inhibitory interneurons and excitatory motor neurons are the sites of action in nematodes, while neuromuscular junctions are the sites of action in arthropods. The exorcism rate of Osteria, CyPERus, Strongylodes (including Strongylodes Eichlii), Strongylodes, Nematodes invertebratus, Nematodes capillaris, Nematodes oesophagostomata, Nematodes reticulata and adult and fourth stage larvae of Chabot sheep was 97%~100%. It is also effective against arthropods such as maggots, worms and lice. It is less effective on chewing lice and sheep ticks. Ivermectin is also highly effective against ticks and flies that reproduce in their faeces. The drug does not kill ticks immediately, but it can affect feeding, molting and egg laying, thereby reducing fertility. Similar effects on blood flies. It was also effective against intestinal trichinella (not effective against muscle trichinella). It also had good control effect on pig blood lice and scabietic end. Ineffective against trematodes and terminalis|
|Pharmacokinetics||The pharmacokinetics of ivermectin vary significantly with different animal species, dosage forms and routes of administration. The bioavailability of subcutaneous injection is higher than that of internal administration, but internal administration is more rapidly absorbed than subcutaneous injection. After absorption, it can be well distributed to most tissues, but not easily into cerebrospinal fluid. The apparent distribution volumes of sheep and pigs were 4.6Lkg and 4L/kg, respectively. In most animals there is a long half-life, 2 to 7 days in sheep and 0.5 days in pigs. This product is metabolized in the liver, mainly lightened in sheep and mainly methylated in pigs. It is mainly excreted from the feces, less than 5% of which is excreted in the urine as protoforms or metabolites. In lactating cows up to 5% of the dose is discharged from the milk.|
|Drug interaction||May produce severe or fatal encephalopathy when used in conjunction with ethylamine.|
|Effects and Uses||Macrolides antiparasitic drugs. Used to control nematodes, acariasis and parasitic insect diseases of sheep and pigs.|
Usage and dosage:For internal administration: one dose, 0.4 tablets per 10kg body weight; The pig 0.6 pieces.
[Adverse reactions] According to the prescribed usage and dosage, no adverse reactions have been observed.
(1) Sheep that produce milk for human consumption shall not be used during lactation.
(2) Ivermectin is highly toxic to shrimp, fish and aquatic organisms. Packaging and containers of residual drugs should not pollute water sources.
(3) Sow should be used with caution during the first 45 days of gestation.
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