||Enrofloxacin 5%/10% Injection
||Cattle, Fowl, Horse, Dogs, Swine, Sheep
||Within 35 days after receiving payment
Cattle, sheep and goat: It is applied for treatment of secondary bacterial and mycoplasma infections of respiratory system (Mycoplasma, Pasteurella, Haemophilus and Staphylococcus) and digestive system infections (E.Coli and Salmonella) and also in treatment of Enzootic calf pneumonia.
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Each ml contains 50 mg of Enrofloxacin
Mechanism of Action:
Enrofloxacin belongs to the third generation of fluoroquinolones that inhibits DNA Gyrase
in the bacterial nucleus and it can cut DNA to small and inactive pieces.
Enrofloxacin inhibits DNA transcription and its bactericidal effects is revealed. Enrofloxacin is a broad spectrum antibiotic that affects on gram negative bacteria such as E.Coli, Klebsiella, Salmonella, Proteus, Campylobacter, Bordetella, Pasteurella, Haemophilus, Actinobacillus, Brucella and Pseudomonas aeruginosa and gram positive bacteria such as Staphylococcus, Streptococcus, Corynebacterium, Clostridium, Listeria monocytogenes, Truperella (Arcanobacterium) pyogenes, Erysipelothrix rhusiopathiae, Mycoplasma and Chlamydia.
Minimum inhibitory concentration of this drug against these organisms is low. This charachteristic and special pharmacokinetic results in a more effective concentration in a short time. After injection of 2.5 mg/Kg body weight to calves, its concentration will reach to 0.9 mg/ml of blood serum within maximum one hour. Simultaneously its concentration in body tissues such as lungs, heart, liver, kidney and lymphatic system will be 2-3 times higher than in CSF. This drug is excreted through kidneys and other routes. 15-50% of the drug is excreted via urine without any molecular change (by tubular and glumerular filtration). The rest is excreted via faeces. Half life of this drug is 3 hours.
Dosage and administration:
This drug is used through subcutaneous route.
Cattle, sheep and goat: 1 ml per 20 kg body weight for 3-5 days (in treatment of
complex infections increase dosage twice as much as normal dosage).
Do not use in cats less than 8 months of age, dogs less than 12 month of age and heavy breed dogs less than 18 months of age .
In high volumes it is recommended to inject in multi sites instead of one site.
Beef: 7 days after the last injection
Milk: 4 days after the last injection
Do not use in horses, those involved in cartilage and joint disorders and growing animals.
Keep between 15-25° C and away from direct light.